The 2005–06 season in the Honduran Liga Nacional was the 41st in its history and determined the 47th and 48th champions in the league.
[1] The Apertura tournament was played from 6 August to 18 December 2005.
It followed the Honduras 05-06 apertura opening season.
The winner competes in the 2006 UNCAF Club Tournament.
The league games started 21 January 2006 and it finished on 28 May 2006.