[3][4] The Packers also acquired Oakland Raiders three-time Pro Bowl cornerback Charles Woodson through free agency later that day.

The Packers signed two notable free agents, CB Charles Woodson from the Oakland Raiders and DT Ryan Pickett from the St Louis Rams.

[6] Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve at Lambeau Field, Green Bay, Wisconsin[7] The Packers opened the regular season on September 10 with a 26–0 loss to the Chicago Bears, the Packers' first scoreless game since October 17, 1991.

[9] The day after the game the Packers acquired wide receiver Koren Robinson, who was released by the Minnesota Vikings after his second DUI in two years.

at Lambeau Field, Green Bay, Wisconsin[10] The Packers hosted the New Orleans Saints on September 17, losing 34–27.

Brett Favre completed his 400th career touchdown pass on a 75-yard play to rookie Greg Jennings, becoming only the second person (in addition to Dan Marino) to reach 400.

The Packers started running back Vernand Morency as Ahman Green was inactive due to injury.

The Packers had a chance to tie the score with a field goal or take the lead with a touchdown in their final possession, but were unable to do so as quarterback Brett Favre is sacked and fumbles at the St. Louis 18 yard line.

[17] at Dolphin Stadium, Miami Gardens, Florida[18] Coming off their bye week, Green Bay defeated the Miami Dolphins on the road as the Packers defense intercepted quarterback Joey Harrington three times, with Charles Woodson returning one for a touchdown.

On defense, the Packers limited Cardinals rookie quarterback Matt Leinart to 14/35 for 157 yards with one touchdown and one interception.

The Bills were able to score in the fourth quarter with 43 yard touchdown pass to receiver Lee Evans.

With under two minutes remaining in the half, the Packers regained the lead when Brett Favre threw an 82-yard touchdown pass to wide receiver Donald Driver.

Backup quarterback Aaron Rodgers replaced Favre and completed only four out of twelve passes for 32 yards with one fumble.

Rodgers suffered a broken foot in the loss and was placed on injured reserve, thus ending his season.

In the second half, the Packers were able to increase the lead to nine points as quarterback Brett Favre threw a 48-yard touchdown pass to Donald Driver.

Seattle would decrease the Packers lead to two points when quarterback Matt Hasselbeck threw a 23-yard touchdown pass to receiver D.J.

Packers kicker Dave Rayner kicked a 34-yard field goal to decrease the Seahawks lead to three points, but on the next possession, Hasselbeck completed his third touchdown pass to Jerramy Stevens.

[32] at Lambeau Field, Green Bay, Wisconsin[33] The Packers traveled back home for a Week 13 inter-conference fight with the New York Jets.

In the first quarter, Green Bay trailed early as Jets kicker Mike Nugent kicked a 24-yard field goal, while quarterback Chad Pennington completed a 12-yard touchdown pass to receiver Jerricho Cotchery.

In the third quarter, the Packers scored their first points of the game when Dave Rayner kicked a 34-yard field goal.

Later in the third quarter Brett Favre completed a 20-yard touchdown pass to wide receiver Donald Driver.

At the end of the first quarter, the game was tied after field goals by Dave Rayner and Jason Hanson.

In the fourth quarter, Brett Favre threw his third interception out of the Packers end zone which put the Lions at the twelve-yard line.

On the next possession the Packers increased their lead to eight points when Vernand Morency ran 21 yards for his second touchdown of the day.

In the first quarter, the Packers entered the red zone on each of their drives, but only scored once on a 38-yard field goal from kicker Dave Rayner.

The Packers drove the ball 41 yards on their next possession to set Dave Rayner in position to attempt a field goal.

However, the Packers were all but eliminated from the playoffs when the New York Giants effectively clinched the decisive tie-breaker (strength of victory) with a win on December 30.

On the first drive of the game, the Packers drove the ball 75 yards, resulting in a 9-yard touchdown pass from Brett Favre to receiver Donald Driver.

Later in the first quarter, Packers free safety Nick Collins intercepted quarterback Rex Grossman, returning the ball 55 yards for a touchdown.

The Bears scored their first and only points of the game with a 75-yard touchdown pass to receiver Mark Bradley from Brian Griese in the third quarter.