This was the franchise’s first year without their star wide receiver Jimmy Smith, as he retired in the offseason.

Front office Head coaches Offensive coaches Special teams coaches Strength and conditioning Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

The Jaguars' defense effectively limited the Colts' offense to 66 yards and 3 first downs in the first half.

However, the Jaguars could not capitalize on this strong defensive performance due to several errors.

Ultimately, the Colts managed to score two touchdowns, securing a 21–14 victory.

Manning achieved a completion rate of under 50 percent, connecting on 14 out of 31 attempts for a total of 219 yards.

Following an interception thrown by Manning, Jones-Drew added a 48–yard rushing touchdown.

The running backs' collective rushing performance played a pivotal role in securing a decisive 44–17 victory against the Colts.