The Titans signed Pittsburgh Steelers safety Chris Hope, Indianapolis Colts linebacker David Thornton, New England Patriots wide receiver David Givens, New York Jets center Kevin Mawae, Oakland Raiders quarterback Kerry Collins, and brought back defensive lineman Robaire Smith after he was released by the Houston Texans.
Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Apart from their regular games with AFC South division rivals, the Titans played against the AFC East and NFC East according to the NFL's schedule rotation, and also played against the Ravens and the Chargers, who in 2005 had like the Titans each finished third in their division.
In the third quarter, things didn't get any better, as opposing kicker Mike Nugent kicked an 18-yard field goal to make Tennessee trail 16–0.
In the fourth quarter, the Titans made a valiant attempt to come back, as RB Travis Henry got a 3-yard and a 1-yard TD run, which were both followed by successful two-point conversions.
Things only got worse in the second quarter, as San Diego unleashed their ultimate weapon, RB LaDainian Tomlinson, as he got a 4-yard and an 8-yard TD run and Kaeding got a 31-yard field goal to give Tennessee a 20–0 halftime deficit.
In the fourth quarter, the game was put well out of reach as opposing QB Philip Rivers completed a 12-yard TD pass to WR Vincent Jackson.
The Titans took the lead before halftime as QB Kerry Collins completed a 27-yard TD pass to TE Bo Scaife in the second quarter.
The Titans started their rookie quarterback Vince Young after veteran Kerry Collins produced dismal results after the first 3 games of the season.
The Titans were held to two field goals in the first half while the Cowboys had a lead at halftime with two 13-yard TD passes from Drew Bledsoe to WR Terry Glenn to put them up 14–6.
In the third quarter, Tennessee got an unpleasant wake-up call, as Colts QB Peyton Manning completed a 13-yard TD pass to WR Marvin Harrison.
Tennessee remained winless on the year, as Manning completed a 2-yard TD pass to WR Reggie Wayne in the fourth quarter.
On the Skins next possession, Titans FB Casey Cramer blocked a Derrick Frost punt out of the end zone for a safety.
Skins RB Portis ran for his second touchdown early in the fourth quarter, and Brunell hit WR Santana Moss for the two-point conversion to tie the game at 22.
at LP Field, Nashville, Tennessee |Weather=74 °F or 23.3 °C (Sunny) Coming off their Bye Week, the Titans went home for an AFC South battle with the Houston Texans.
In the fourth quarter, Adam "Pacman" Jones helped the Titans boost their lead by returning a punt 53 yards for a touchdown.
In the fourth quarter, Tennessee got their only score of the game, as QB Vince Young completed a 32-yard TD pass to WR Drew Bennett.
at LP Field, Nashville, Tennessee |Weather=47 °F or 8.3 °C (Sunny) Hoping to rebound from their road loss to the Jaguars, the Titans went home for a Week 10 fight, as QB Vince Young went up against his predecessor (Steve McNair) and the Baltimore Ravens.
Afterwards, Young got a 2-yard TD run to give Tennessee the lead, while DE Tony Brown sacked McNair in the end zone for a safety.
However, the Ravens responded with McNair completing a 30-yard TD pass to FB Ovie Mughelli, followed up by kicker Matt Stover's 27-yard field goal.
After a scoreless third quarter, Baltimore wrapped things up against Tennessee with Stover getting a 40-yard field goal and McNair completing an 11-yard TD pass to WR Derrick Mason.
at LP Field, Nashville, Tennessee |Weather=70 °F or 21.1 °C (Mostly Cloudy) Trying to build on their road win over the Eagles, the Titans went home for a Week 12 fight with the New York Giants.
In the first quarter, Tennessee trailed early as QB Eli Manning completed a 3-yard TD pass to WR Plaxico Burress for the only score of the period.
The key play of the game came on a 4th and 10 from Tennessee's 24-yard line, when Giants DE Mathias Kiwanuka had Young in his grasp, but he let go thinking the quarterback had thrown the ball.
Afterwards, after Manning got intercepted for the second time by CB Pacman Jones, kicker Rob Bironas nailed a game-winning field goal it from 49 yards out.
at LP Field, Nashville, Tennessee |Weather=41 °F or 5 °C (Mostly Cloudy) After scratching off one Manning in one thriller, the Titans stayed at home for an AFC South rematch with their archrival Indianapolis Colts.
In the first quarter, the Colts struck first with QB Peyton Manning completing a 68-yard TD pass to WR Marvin Harrison for the only score of the period.
The Titans started to creep back into the game, with kicker Rob Bironas getting a 25-yard field goal, while QB Vince Young completed a 20-yard TD pass to WR Drew Bennett.
The Titans won the coin toss in overtime, and Young ended the game in dramatic fashion with a 39-yard TD run on a 3rd-and-14 early in the extra period.
at LP Field, Nashville, Tennessee |Weather=62 °F or 16.7 °C (Light Rain) Needing one more win to get into the playoffs, the Titans (8–7) wrapped up the regular season at home against the New England Patriots.
The Patriots responded when kicker Stephen Gostkowski hit a 28-yard field goal, and then took the lead after RB Corey Dillon scored a 21-yard TD run, though the subsequent extra point attempt failed.