In the second quarter, the Cardinals responded with QB Kurt Warner completing a one-yard TD pass to WR Larry Fitzgerald, yet San Francisco tied the game with kicker Joe Nedney getting a 39-yard field goal.

In the third quarter, the Cardinals tied the game with kicker Neil Rackers nailing a 26-yard field goal, yet Washington responded with QB Jason Campbell completing a two-yard TD pass to TE Todd Yoder.

In the third quarter, the Bills tried to come back as kicker Rian Lindell got a 48-yard field goal, but Arizona kept its intensity up as Warner completed a two-yard TD pass to Fitzgerald.

In the fourth quarter, the Cardinals regained the lead as Warner completed an 11-yard TD pass to WR Steve Breaston, along with kicker Neil Rackers getting a 41-yard field goal.

However, the Cowboys tied the game as Romo completed a 70-yard TD pass to RB Marion Barber, along with kicker Nick Folk nailing a 52-yard field goal.

In overtime, after forcing a three-and-out, Arizona got the win as WR Sean Morey blocked a Mat McBriar punt attempt, allowing LB Monty Beisel to return it 3 yards for the game-winning touchdown.

In the second quarter, Arizona increased its lead as QB Kurt Warner completed a five-yard TD pass to WR Anquan Boldin.

Hoping to rebound from their road loss to the Panthers, the Cardinals flew to the Edward Jones Dome for a Week 9 NFC West duel with the St. Louis Rams.

Coming off their divisional road win over the Rams, the Cardinals went home for a Week 10 NFC West rematch with the San Francisco 49ers on Monday Night Football.

In the third quarter, Arizona crept closer again as Warner completed a five-yard TD pass to WR Larry Fitzgerald, yet San Francisco replied with kicker Joe Nedney getting a 41-yard field goal.

In the fourth quarter, the Cardinals took the lead as Rackers nailed a 23-yard field goal, along with Warner hooking up with Boldin again on a five-yard TD pass (with a failed two-point conversion.)

Coming off their close MNF home win over the 49ers, the Cardinals flew to Qwest Field for a Week 11 NFC West duel with the Seattle Seahawks.

In the third quarter, the Cardinals increased their lead as Rackers nailed a 26-yard field goal and QB Kurt Warner completed a six-yard TD pass to Arrington.

The Cardinals would regain the lead with rookie RB Tim Hightower getting a four-yard TD run (with a failed extra-point attempt), yet New York answered with kicker John Carney getting a 33-yard field goal.

The Cardinals would reply with Rackers making a 20-yard field goal, yet the Giants closed out the half with QB Eli Manning completing a 12-yard TD pass to WR Amani Toomer.

In the fourth quarter, the Giants were starting to pull away as Manning completed a 10-yard TD pass to TE Kevin Boss, while Carney made a 27-yard field goal.

The Cardinals tried to keep pace as QB Kurt Warner completed a five-yard TD pass to WR Anquan Boldin, yet New York replied with Carney's 33-yard field goal.

Hoping to rebound from their tough home loss to the Giants, the Cardinals flew to Lincoln Financial Field for a Week 13 Thanksgiving battle with the Philadelphia Eagles.

In the third quarter, Cardinals linebacker, Gerald Hayes, would force two Steven Jackson fumbles, the second one recovered by Darnell Dockett, who would return it 11 yards to the end zone for a touchdown.

The Cardinals would rally to cut the lead in half with a Jerheme Urban 50-yard TD catch and a field goal blocked by Dominique Rodgers-Cromartie and recovered by Roderick Hood, who returned it 68 yards for a touchdown.

In the third quarter, Arizona's deficit continued to climb as Cassel completed a 76-yard touchdown pass to wide receiver Randy Moss, followed by Gostkowski's 35- and 24-yard field goals.

Seattle tried to rally in the fourth quarter as Wallace completed a two-yard touchdown pass to Branch, yet the Cardinals would close out the game with kicker Neil Rackers nailing 23 and 32-yard field goals.

The Falcons responded with kicker Jason Elam's 30-yard field goal, yet the Cardinals struck right back as Warner completed a 71-yard touchdown pass to wide receiver Anquan Boldin.

The Falcons tried to come back as Ryan completed a five-yard touchdown pass to wide receiver Roddy White, yet Arizona's offense drained any second that Atlanta needed to rally.

Coming off their wild card home win over the Falcons, the Cardinals flew to Bank of America Stadium for the NFC Divisional round against the #2 Carolina Panthers, in a rematch of their Week 8 contest.

In the second quarter, Arizona took control as kicker Neil Rackers made a 49-yard and then a 30-yard field goal, followed by Warner's 29-yard touchdown pass to wide receiver Larry Fitzgerald.

Carolina would end the game's scoring with quarterback Jake Delhomme's eight-yard touchdown pass to wide receiver Steve Smith (with a failed two-point conversion.)

Arizona's defense forced Delhomme into six turnovers (five interceptions and one fumble), along with holding the Panthers' running back duo of Williams and Stewart to 74 combined rushing yards.

The Cardinals improved their overall record to 12–7, and also won their first National Football Conference crown, allowing them to advance to their first Super Bowl appearance in franchise history.

Two weeks following their NFC Championship victory over the Eagles, the Cardinals flew to Tampa, Florida for their Super Bowl XLIII duel with the AFC Champion Pittsburgh Steelers at Raymond James Stadium.