The Jaguars lost starting guards Vince Manuwai and Maurice Williams for the season within the first quarter of the opening game.

Tackle Richard Collier's career ended in early September when he was brutally attacked and shot 14 times.

[1] Center Brad Meester missed the first two months of the season and guard Chris Naeole, signed to the roster mid-season in response to these injuries, was injured in pregame warmups before playing a single snap.

However, the Jaguars overall struggled, especially in the second half of the season, as evidenced by a 21–19 loss to the Bengals, who entered the game with an 0–8 record.

Source:[2] On September 2, 2008, third-year offensive tackle Richard Collier was shot outside an apartment building in Jacksonville while waiting for his girlfriend with a friend of his, former teammate Kenny Pettway, in his Cadillac Escalade.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.