However, after a 3–4 start on the season Peyton Manning led the Colts to a nine-game winning streak, a 12–4 record, and a wild card berth in the playoffs.
In the third quarter, Indianapolis tried to rally as QB Peyton Manning completed a 6-yard TD pass to WR Reggie Wayne, yet the Bears replied with LB Lance Briggs returned a fumble 21 yards for a touchdown.
In the fourth quarter, the Colts drew closer as QB Peyton Manning completed a 32-yard TD pass to WR Reggie Wayne, followed by a 2-point conversion run by RB Dominic Rhodes.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Coming off their last-second road win over the Vikings, the Colts went home for a Week 3 AFC South duel with the Jacksonville Jaguars.
In the second quarter, the Jaguars took the lead with kicker Josh Scobee getting a 26-yard field goal, along with CB Rashean Mathis returning an interception 61 yards for a touchdown.
In the first quarter, Indianapolis drew first blood as kicker Adam Vinatieri got a 46-yard field goal, along with RB Joseph Addai getting a 1-yard TD run.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Coming off their comeback divisional road win over the Texans, the Colts went home for a Week 6 duel with the Baltimore Ravens.
In the third quarter, the Packers increased their lead as Free Safety Nick Collins returned an interception 62 yards for a touchdown, along with Crosby nailing a 29-yard field goal.
In the fourth quarter, Green Bay finished its domination as Safety Aaron Rouse returned an interception 99 yards for a touchdown.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Trying to rebound from their MNF divisional road loss to the Titans, the Colts went home for a Week 9 Sunday night duel with their hated rival, the New England Patriots.
In the first quarter, Indianapolis got off to a fast start as QB Peyton Manning completed a 12-yard TD pass to WR Anthony Gonzalez.
The Colts immediately responded with QB Peyton Manning completing a 65-yard TD pass to WR Reggie Wayne.
Indianapolis took the lead as Manning completing a 17-yard TD pass to RB Dominic Rhodes, along with the defense preventing any Pittsburgh comeback.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Coming off their road win over the Steelers, the Colts went home for a Week 11 AFC South rematch with the Houston Texans.
On the Texans' final drive, QB Sage Rosenfels was intercepted by safety Melvin Bullitt (who was filling in again for the injured Bob Sanders).
Ironically,[citation needed] it was Bullitt who picked off Rosenfels on the Texans' final drive when they played the Colts in Week 5.
In the second quarter, the Chargers took the lead as kicker Nate Kaeding made a 35-yard field goal, while QB Philip Rivers completed a 39-yard TD pass to WR Vincent Jackson.
San Diego cut the Colts' lead to 3 as Rivers completed a 1-yard TD pass to FB Jacob Hester, and then Kaeding kicked a 47-yard field goal to tie the game.
By making the kick, Vinatieri redeemed himself after missing a game-winning 29-yard field goal against San Diego in the previous season.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana With a low-scoring road win over the Browns behind them, the Colts went home for a Week 14 game with the Cincinnati Bengals.
The Bengals would answer in the second quarter with kicker Shayne Graham nailing a 19-yard field goal, yet Indianapolis replied with QB Peyton Manning completing a 5-yard TD pass to WR Marvin Harrison.
Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Coming off their win over the Bengals, the Colts stayed at home for their Week 15 interconference game with the winless Detroit Lions.
Indianapolis would close out the half quarterback Peyton Manning completing a 3-yard touchdown pass to tight end Dallas Clark.
Indianapolis trailed early in the first quarter as Jaguars David Garrard completed a 28-yard touchdown pass to wide receiver Dennis Northcutt.
The scoreless Colts possession left 1:03 on the clock, enough time to enable Jacksonville to close out the half with a 44-yard field goal from kicker Josh Scobee.
The Jaguars would get a late-game drive into Colts' territory, yet defensive end Dwight Freeney delivered the game-winning sack, preserving Indianapolis' slim lead.
[23] Scoring Summary at Lucas Oil Stadium, Indianapolis, Indiana Coming off their playoff-clinching road win over the Jaguars, the Colts closed out the regular season at home in a Week 17 AFC South rematch with the Tennessee Titans.
The Titans, having already clinched the number one seed in the AFC and having home-field advantage, only played second- and third-string players for the entirety of the game.
Indianapolis would get the early first quarter lead as quarterback Peyton Manning completed a 55-yard touchdown pass to running back Joseph Addai, followed by kicker Adam Vinatieri getting a 28-yard field goal.
Afterwards, in overtime, the Colts would never get the ball as San Diego took the period's first drive and capped it off with Sproles' game-ending 22-yard touchdown run.