The 2008 season was the San Francisco 49ers' 59th in the National Football League (NFL), their 63rd overall, and their fourth and final under the head coach Mike Nolan.

In the second quarter, Arizona regained the lead with QB Kurt Warner completing a 1-yard TD pass to WR Larry Fitzgerald.

In the third quarter, the Cardinals began to fly away as Rackers nailed a 31-yard field goal, along with RB Tim Hightower getting a 2-yard TD run.

In the first quarter, the Niners trailed early as Seahawks RB Julius Jones got a 27-yard TD run, along with DT Craig Terrill returning a fumble 10 yards for a touchdown.

In the third quarter, San Francisco took the lead with LB Patrick Willis returning an interception 86 yards for a touchdown and RB Frank Gore getting a 2-yard TD run.

The Lions responded with a 44-yard field goal by kicker Jason Hanson, yet the 49ers replied in the fourth quarter with CB Allen Rossum getting a 1-yard TD run.

Detroit tried to rally as QB Jon Kitna completed a 34-yard TD pass to RB Rudi Johnson, but San Francisco sealed their victory with kicker Joe Nedney nailing a 25-yard field goal.

San Francisco answered with Nedney's 49-yard field goal, yet New Orleans replied with Brees' 47-yard TD pass to WR Robert Meachem.

O'Sullivan completed a 5-yard TD pass to WR Isaac Bruce, yet New Orleans sealed the win with kicker Martín Gramática nailing a 31-yard field goal.

at Candlestick Park, San Francisco Hoping to rebound from their road loss to the Saints, the 49ers went home for a Week 5 interconference duel with the New England Patriots.

In the second quarter, New England took the lead as kicker Stephen Gostkowski got a 35-yard field goal, along with RB Kevin Faulk getting a 2-yard TD run.

The Niners tried to come back as O'Sullivan completed a 5-yard TD pass to Bruce, but the Patriots pulled away with Gostkowski nailing a 49-yard field goal.

at Candlestick Park, San Francisco Hoping to snap a two-game losing skid, the 49ers stayed at home for a Week 6 duel with the Philadelphia Eagles.

In the second quarter, Philadelphia increased their lead as QB Donovan McNabb completed a 2-yard TD pass to WR Hank Baskett, along with kicker David Akers getting a 19-yard field goal.

In the third quarter, New York increased its lead with QB Eli Manning completing a 6-yard TD pass to WR Plaxico Burress.

at Candlestick Park, San Francisco Hoping to rebound from their road loss to the Giants, the 49ers went home for a Week 8 NFC West rematch with the Seattle Seahawks.

San Francisco got on the board with kicker Joe Nedney getting a 42-yard field goal, but the Seahawks continued its beatdown as CB Josh Wilson returned an interception 75 yards for a touchdown.

In the third quarter, the 49ers replied with Nedney making a 40-yard field goal, yet Seattle continued to pull away as QB Seneca Wallace completed a 43-yard TD pass to FB Leonard Weaver.

In the first quarter, the Niners immediately struck first as CB Allen Rossum returned the game's opening kickoff 104 yards for a touchdown.

In the second quarter, San Francisco increased their lead as Hill completed a 31-yard TD pass to rookie WR Josh Morgan.

Arizona responded with QB Kurt Warner completing a 13-yard TD pass to WR Anquan Boldin, along with Rackers making a 33-yard field goal.

In the third quarter, the Cardinals tried to catch up as Warner completed a 5-yard TD pass to WR Larry Fitzgerald, yet the 49ers answered with kicker Joe Nedney getting a 41-yard field goal.

In the fourth quarter, Arizona took the lead as Racker nailed a 23-yard field goal, along with Warner hooking with Boldin again on a 4-yard TD pass (with a failed 2-point conversion).

at Candlestick Park, San Francisco Trying to snap a six-game losing streak, the 49ers went home for a Week 11 NFC West duel with their hated rival, the St. Louis Rams.

Dallas continued its domination as LB Carlos Polk blocked punter Andy Lee's punt into the back of the endzone for a safety.

The Cowboys closed out its period of power as kicker Nick Folk got a 48-yard and a 41-yard field goal, along with Romo completing a 1-yard TD pass to TE Martellus Bennett.

The 49ers tried to come back as QB Shaun Hill completed an 18-yard TD pass to WR Isaac Bruce, but Dallas replied with Folk nailing a 42-yard field goal.

The Niners tried to rally as Hill completed a 9-yard TD pass to RB DeShaun Foster, but that was as close as San Francisco's comeback got.

On the ensuing 49ers possession, a Shaun Hill touchdown pass to Delanie Walker was called back, and the 49ers settled for a Joe Nedney 32-yard field goal.

The Redskins tied the game as Campbell getting a 2-yard touchdown run, yet the Niners prevailed as Nedney nailed the game-winning 39-yard field goal.