Their running attack was headlined by the trio of Brandon Jacobs, Derrick Ward, and Ahmad Bradshaw, respectively nicknamed "Earth, Wind, and Fire."

In the first quarter, New York got a fast start as Super Bowl XLII MVP QB Eli Manning capped off the game's opening drive with a 1-yard TD run.

Near the end of the half, the Redskins managed to get on the board as QB Jason Campbell completed a 12-yard TD pass to WR Santana Moss.

In the fourth quarter, the Rams tried to rally as QB Marc Bulger completed a 45-yard TD pass to WR Torry Holt.

Cincinnati replied with RB Chris Perry getting a 25-yard TD run, yet the Giants managed to tie the game with kicker John Carney getting a 24-yard field goal.

In overtime, after exchanging punts, Manning led the Giants on a 6 play, 66-yard game winning drive, with Carney kicking a 22-yard field goal.

In the third quarter, the Giants continued their victory march as Manning completed a 23-yard TD pass to WR Sinorice Moss, along with Carney nailing a 35-yard field goal.

In the fourth quarter, Cleveland pulled away as Anderson completed an 11-yard TD pass to WR Braylon Edwards and CB Eric Wright returned an interception 94 yards for a touchdown.

In the third quarter, New York added onto their lead as QB Eli Manning completed a 6-yard TD pass to WR Plaxico Burress.

In the third quarter, Pittsburgh regained the lead with QB Ben Roethlisberger completing a 65-yard TD pass to WR Nate Washington.

In the fourth quarter, Dallas tried to rally as QB Brooks Bollinger completed an 8-yard TD pass to WR Terrell Owens.

The Giants responded with QB Eli Manning completing a 17-yard TD pass to WR Plaxico Burress, along with kicker John Carney getting a 27-yard field goal.

In the second quarter, New York increased their lead as QB Eli Manning completed a 1-yard TD pass to TE Darcy Johnson.

The Giants would regain the lead prior to halftime as QB Eli Manning completed a 12-yard TD pass to WR Amani Toomer.

In the fourth quarter, New York greatly increased their lead as Manning completed a 10-yard TD pass to TE Kevin Boss.

Arizona would respond with QB Kurt Warner completing a 5-yard TD pass to WR Anquan Boldin, yet the Giants answered with Carney getting a 33-yard field goal.

On Friday, November 28, 2008, Giants wide receiver Plaxico Burress suffered an accidental self-inflicted gunshot wound to the right thigh in a New York City nightclub when his gun, tucked in the waistband of his sweatpants, began sliding down his leg.

[13] Later in the day, Burress reported to Giants Stadium as per team policy for injured but active players, and was told he would be suspended without pay.

In the first quarter, New York scored first as QB Eli Manning completed a 40-yard TD pass to WR Amani Toomer, along with kicker John Carney getting a 31-yard field goal.

With the season-sweep, the Giants improved to 11–1, exceeding the 1986 and 1990 teams (both started 10–2 and eventually won the Super Bowl) for the best 12-game record in franchise history.

With 7 seconds left in the 1st half, the Eagles attempted to go up 13–0 with a field goal, instead, the kick was blocked and returned 71 yards by Kevin Dockery for a Giants touchdown.

Brandon Jacobs was sidelined with a knee injury, crippling New York's running game; Derrick Ward started in his place.

On the Cowboys' next drive, deep in their own territory, Mathias Kiwanuka sacked Romo and forced a fumble in the end zone, which resulted in a safety.

After the teams traded punts the Giants scored with 0:55 remaining in the half as Carney added his second field goal of the game.

New York tied the game with 3:24 remaining as Jacobs scored on a one-yard touchdown run, after starting the drive in Panther territory.

New York rested most of their starters in the second half and Brandon Jacobs, Kevin Boss, Aaron Ross, and Barry Cofield were held out of the game due to injuries.

Minnesota scored a touchdown on a long pass from Tarvaris Jackson to Bernard Berrian on their next drive, cutting the Giants lead to 19–17.

Jackson then led the Vikings into field goal range and Longwell hit from 50 yards out to win the game as time expired.

The Giants would answer in the second quarter as the defense forced McNabb into an intentional grounding penalty from his own endzone, giving them a safety.

In the fourth quarter, Philadelphia took control as McNabb completed a 1-yard touchdown pass to tight end Brent Celek, followed by Akers nailing a 20-yard field goal.