The 2009–10 Mississippi Valley State Delta Devils basketball team represented Mississippi Valley State University during the 2009–10 NCAA Division I men's basketball season.

The Delta Devils, led by second year head coach Sean Woods, played their home games at Harrison HPER Complex as members of the Southwestern Athletic Conference.

The Delta Devils finished the season 9–23 overall and 8–10 in SWAC conference play.

They lost 69–66 in the first round of the SWAC Basketball tournament to Arkansas-Pine Bluff.

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