The 2010–11 Mississippi Valley State Delta Devils basketball team represented Mississippi Valley State University during the 2010–11 NCAA Division I men's basketball season.

The Delta Devils, led by third year head coach Sean Woods, played their home games at Harrison HPER Complex as members of the Southwestern Athletic Conference.

The Delta Devils finished the season 13-19 overall and 12-6 in SWAC conference play.

They lost 65-62 in the first round of the SWAC Basketball tournament to Grambling State.

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