The knockout phase of the 2009–10 UEFA Champions League began on 16 February and concluded on 22 May 2010 with the final won by Internazionale against Bayern Munich 2–0 at the Santiago Bernabéu Stadium in Madrid.
If no goals were scored during extra time, the tie was settled via a penalty shoot-out.
The draw mechanism for each round is as follows: In the final, the tie was played over just one leg at a neutral venue.
[2] Starting from this season, the matches in the round of 16 were held over a month, instead of the previous two weeks.
[7] There were fears that the first legs would have to be postponed due to the eruptions of the volcano at Eyjafjallajökull in Iceland.
On 18 April, UEFA issued a statement that the matches would go ahead and that the teams would have to make alternate travel arrangements.
[9] The stadium, home of Real Madrid, had hosted three previous European Cup finals, in 1957, 1969 and 1980.
[10] It was the first time that a UEFA Champions League final was played on a Saturday night.