The first training session for the season took place on June 14, 2010 at GSP Stadium.

The team finished 2nd in the Cypriot championship the previous season and as such entered the UEFA Europa League 2010–11 second qualifying round.

During the 2010–11 season APOEL reached the Europa League Play-off round being eliminated by Getafe CF 2–1 on aggregate, eliminated in the 2nd round of Cypriot Cup by Apollon 3–1 on aggregate, but finished the season with an emphatic way by winning the Championship four games before the end of the season, creating that day an advantage of 15 points from its main competitor and arch rivals Omonoia.

Last Update: January 6, 2011[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

All times for the Domestic Competitions at EET APOEL won 6–1 on aggregate.