2010 AFC Champions League knockout stage

Note: while the bracket below shows the entire knockout stage, the draw for the round of 16 matches was determined at the time of the group draw, and kept teams from East and West Asia completely separate for that round.

The draw for the quarter-finals and beyond was held separately, after the conclusion of the round of 16.

Therefore, the two clubs from Saudi Arabia may not be drawn with each other in the quarter-finals.

Therefore, the four clubs from the Korea Republic may be drawn against each other in the quarter-finals.

Seongnam Ilhwa Chunma won on away goals.