The 2010 Cincinnati Bearcats football team represented the University of Cincinnati as a member of the Big East Conference during the 2010 NCAA Division I FBS football season.

Led by first-year head coach Butch Jones, the Bearcats were compiled an overall record of 4–8 with a mark of 2–5 in conference play, placing seventh in the Big East.

Cincinnati played six home games at Nippert Stadium and one at Paul Brown Stadium.

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