The 2010 season was the Kansas City Chiefs' 41st in the National Football League (NFL), their 51st overall and their second under the head coach/general manager tandem of Todd Haley and Scott Pioli.

They had an additional second round pick from the Atlanta Falcons in a trade that sent tight end Tony Gonzalez to the Falcons and two additional fifth round picks, one of them coming from the Carolina Panthers in a trade that sent defensive end Tank Tyler to the Panthers, and the other coming from the Miami Dolphins in exchange for quarterback Tyler Thigpen.

In the first quarter the Chiefs trailed early as QB Philip Rivers completed a 3-yard TD pass to TE Antonio Gates.

In the 2nd quarter the Chiefs took the lead with QB Matt Cassel completing a 2-yard TD pass to TE Tony Moeaki.

In the third quarter the Chargers cut the lead when QB Philip Rivers threw a 59-yard TD pass to WR Legedu Naanee.

The Chiefs fell behind in the 2nd quarter when RB Peyton Hillis completed a 1-yard TD run, but got back in the game when CB Brandon Flowers returned an interception 33 yards to the endzone for a touchdown.

In the 2nd quarter, the Chiefs scored first when QB Matt Cassel made a 31-yard TD pass to WR Dexter McCluster.

But the Chiefs started to rally with kicker Ryan Succop getting a 32-yard field goal, followed by Cassel making a 45-yard TD pass to WR Dwayne Bowe.

With losses by both the Chicago Bears and the Pittsburgh Steelers the following week, the Kansas City Chiefs are left as the last undefeated team.

In the first quarter the Chiefs took the early lead with QB Matt Cassel getting a 2-yard TD pass to OLB Mike Vrabel.

The Texans responded and tied the game with QB Matt Schaub making a 5-yard TD pass to TE Joel Dreessen.

The Jaguars took the lead in the second quarter with QB Todd Bouman making an 18-yard TD pass to RB Maurice Jones-Drew.

Late in the second quarter the Chiefs took the lead as QB Matt Cassel got a 1-yard TD pass to WR Dwayne Bowe.

The Bills responded and tied the game with Ryan Fitzpatrick throwing a 4-yard TD pass to WR Stevie Johnson.

Coming off their win over the Bills the Chiefs flew to Oakland–Alameda County Coliseum for an AFC West division rivalry match against the Raiders.

In the 2nd quarter the Chiefs took the lead as QB Matt Cassel made an 11-yard TD pass to WR Verran Tucker; followed by kicker Ryan Succop nailing a 43-yard field goal.

Hoping to rebound from their loss to the Raiders the Chiefs flew to INVESCO Field at Mile High for a division rivalry match against the Broncos.

The Chiefs tried to come back when QB Matt Cassel made a 5-yard TD pass to RB Jamaal Charles, followed by kicker Ryan Succop hitting a 40-yard field goal.

The Chiefs tried narrow the lead with Cassel making an 11 and a 22-yard TD pass to WR Chris Chambers and Dwayne Bowe respectively (With failed 2-point conversions for each), but the defense prevented their chances.

Hoping to break their two-game losing streak the Chiefs played on home ground for an inter-conference duel with the Cardinals.

The Chiefs trailed early with kicker Jay Feely hitting a 36-yard field goal, but they took the lead with QB Matt Cassel completing a 1-yard TD pass to WR Dwayne Bowe.

Coming off their win over the Cardinals the Chiefs flew to Qwest Field where they played their old division rival, the Seattle Seahawks.

They had a problem maintaining this lead as Dustin Colquitt's punt was blocked and returned 10 yards for a touchdown by FS Earl Thomas.

The lead was narrowed when kicker Olindo Mare got a 43-yard field goal, followed by QB Matt Hasselbeck getting a 13-yard TD pass to TE Chris Baker.

Coming off their win over the Seahawks the Chiefs played on home ground for an AFC West rivalry rematch against the Broncos.

This was followed in the fourth quarter by kicker Nate Kaeding nailing a 48-yard field goal, and then by RB Ryan Mathews getting a 15-yard TD run.

This was followed by kicker Ryan Succop nailing a 35-yard field goal, then with Cassel making a 75-yard TD pass to WR Dwayne Bowe.

The Titans responded as QB Kerry Collins got a 53-yard TD pass to WR Kenny Britt, but the Chiefs extended their lead with SS Eric Berry returning an interception 54 yards for a touchdown.

Later in the day, the Chiefs clinched their sixth AFC West division title when San Diego lost at Cincinnati.

With the loss, not only did the Chiefs' season come to an end with an overall record of 10–7, but they also lost their NFL worst 7th straight postseason game.