An additional victory would have allowed the Chargers to win the AFC West on a tiebreaker, but they instead finished a game behind the Kansas City Chiefs.
In the first quarter the Chargers took the early lead as QB Philip Rivers completed a 3-yard TD pass to TE Antonio Gates.
In the third quarter the Chargers cut the lead when QB Philip Rivers threw a 59-yard TD pass to WR Legedu Naanee.
The Chargers continued to score with Rivers making a 4-yard TD pass to Gates; followed in the 3rd quarter by kicker Nate Kaeding getting a 41-yard field goal.
The Chargers cut the lead with QB Philip Rivers getting a 3-yard TD pass to WR Malcolm Floyd, followed by Hasselbeck getting sacked by ILB Brandon Siler in the endzone for a safety.
The Seahawks increased their lead when Mare made a 23-yard field goal, but the Chargers replied and tied the game when Rivers found TE Antonio Gates on a 12-yard TD pass.
Before the clock struck zero Seattle took the winning score as RB Leon Washington returned his second kickoff of the game into the endzone running 99 yards for a touchdown, giving the Chargers the loss.
Coming off their win over the Cardinals the Chargers flew to Oakland–Alameda County Coliseum for an AFC West division rivalry match against the Raiders.
In the first quarter the Chargers' offense had problems when after a three-and-out Mike Scifres' punt was blocked by RB Rock Cartwright out of bounds in the end zone for a safety.
The Chargers then fought back and took the lead with QB Philip Rivers completing a 19-yard TD pass to TE Antonio Gates.
In the first quarter San Diego trailed early as kicker Josh Brown made a 39-yard field goal, followed by QB Sam Bradford completing a 38-yard TD pass to WR Danario Alexander.
The Chargers replied with kicker Nate Kaeding nailing a 41-yard field goal, followed in the third quarter by FB Mike Tolbert getting a 1-yard TD run.
In the 4th quarter the Rams' lead increased when Josh Brown hit a 48-yard field goal, but was cut when QB Philip Rivers made a 5-yard TD pass to WR Buster Davis.
The Chargers fell behind with kicker Rob Bironas nailing a 21-yard field goal, followed in the second quarter by QB Vince Young completing a 1-yard TD pass to TE Craig Stevens.
Then QB Philip Rivers completed a 48-yard TD pass to TE Antonio Gates, and then Brown made a 36-yard field goal.
They trailed again with kicker Neil Rackers nailed a 27-yard field goal, but took the lead after Rivers got an 11-yard TD pass to TE Randy McMichael.
Denver would close out the game with quarterback Kyle Orton completing a 13-yard touchdown pass to wide receiver Brandon Lloyd.
Their lead was narrowed when Manning made a 6-yard TD pass to WR Blair White, but the Chargers controlled the second half with Kaeding getting a 30-yard field goal, which was shortly followed by FS Eric Weddle returning an interception 41 yards for a touchdown, then with FB Mike Tolbert getting a 3-yard TD run, and Kaeding making a 20-yard field goal, settling both teams records to 6–5.
The Chargers trailed early as QB Jason Campbell scrambled 9 yards for a touchdown, followed by his 4-yard TD pass to WR Jacoby Ford.
They replied in the second quarter as kicker Nate Kaeding nailed a 39-yard field goal, but trailed further with RB Michael Bush getting a 7-yard TD run.
The Chargers cut the lead with Kaeding hitting a 33-yard field goal, followed by QB Philip Rivers completing a 4-yard TD pass to TE Antonio Gates.
Hoping to rebound from their loss to the Raiders the Chargers played on home ground for an AFC West rivalry rematch against the Chiefs.
This was followed in the fourth quarter by kicker Nate Kaeding nailing a 48-yard field goal, and then by RB Ryan Mathews getting a 15-yard TD run.
The lead was extended in the second quarter by kicker Nate Kaeding nailing a 25-yard field goal, followed by Rivers finding Jackson on an 11-yard touchdown pass.
In the first quarter the Chargers trailed early with QB Carson Palmer throwing a 3-yard TD pass to TE Jermaine Gresham.
The Chargers tried to come back after QB Philip Rivers made a 5-yard TD pass to WR Kelley Washington, but the Bengals defense prevented any more scoring chances.
With Kansas City winning earlier in the day, the loss prevented the Chargers from making their sixth playoff appearance in seven years.
In the first quarter the Chargers trailed early as QB Tim Tebow threw a 14-yard TD pass to WR Brandon Lloyd.
They eventually overcame this deficit with RB Ryan Mathews getting a 27-yard TD run, followed by kicker Nate Kaeding nailing a 42, 45 and 47-yard field goal to put the Chargers up 16–7.
The Chargers finished the 2010–11 NFL season as the only team ever to rank first in overall offense (396 yds/g) and overall defense (272 yds/g), in terms of total yards gained and allowed, and not make the playoffs the same year.