The 2010 season was the New Orleans Saints' 44th in the National Football League (NFL) and their 35th playing home games in the Louisiana Superdome.

The Saints also attempted to win the NFC South Division title for the third time in history, earn their first consecutive postseason berths since 1991, and successfully defend their conference and league championships.

The Saints were eliminated in the first round by the Seattle Seahawks, who were the first team with a losing record (7–9) to qualify for the playoffs and/or win a division title in a full season.

New Orleans would strike first in the opening quarter with quarterback Drew Brees hooking up with wide receiver Devery Henderson on a 29-yard touchdown pass.

The Vikings would take the lead in the second quarter as kicker Ryan Longwell made a 41-yard field goal, followed by quarterback Brett Favre's 20-yard touchdown pass to tight end Visanthe Shiancoe (with a blocked PAT).

Coming off their home win over the Vikings, the Saints flew to Candlestick Park for a Week 2 Monday Night duel with the San Francisco 49ers.

New Orleans would deliver the opening punch in the first quarter as 49ers center David Baas' high snap deep within San Francisco territory went out of the back of the endzone for a safety.

The Saints would add onto their lead as quarterback Drew Brees hooked up with running back Reggie Bush on a 6-yard touchdown pass.

The 49ers would strike back as Gore got a 7-yard touchdown run, followed by Smith's 2-point conversion pass to tight end Vernon Davis.

Hoping to increase their winning streak the Saints played inside their dome for an NFC South rivalry match against the Falcons.

At overtime, the decision was made when Matt Bryant hit a 46-yard field goal to give the Saints their first loss of the season, bringing their record down to 2–1.

The Saints took the lead when kicker John Carney nailed a 32-yard field goal, but fell behind when RB DeAngelo Williams made a 39-yard TD run.

Coming off their close win over the Panthers the Saints flew to University of Phoenix Stadium for an NFC duel with the Cardinals.

In the first quarter the Saints took the early lead as kicker John Carney nailed a 31-yard field goal, followed by QB Drew Brees completing a 1-yard TD pass to TE Jeremy Shockey.

The Cardinals replied with kicker Jay Feely making a 37-yard field goal, followed by OT Levi Brown recovering a fumble and returning it 2 yards for a touchdown.

Hoping to rebound from their loss to the Cardinals the Saints flew to Raymond James Stadium for an NFC South rivalry match against the Buccaneers.

In the fourth quarter, the Saints increased their lead as quarterback Drew Brees found wide receiver Marques Colston on a 16-yard touchdown pass.

Coming off their win over the Steelers the Saints flew to Bank of America Stadium for an NFC South rivalry match against the Panthers.

Then they made a large scoring run to dominate the game after QB Drew Brees completed a 7-yard TD pass to TE Jeremy Shockey.

In the first quarter the Saints trailed early as kicker Olindo Mare hit a 20-yard field goal; but they pulled ahead after RB Chris Ivory got a 1-yard TD run.

The Saints scored with Hartley making a 28-yard field goal, but fell behind with Marion Barber and Tashard Choice getting a 1-yard TD run.

The Saints, down 27–23, were well on their way to defeat when John Kitna hit Austin with a long-gainer, but safety Malcolm Jenkins stripped Roy Williams and recovered at the New Orleans 11, enabling the Saints to pull out the win five plays later, with QB Drew Brees completing a 12-yard TD pass to WR Lance Moore, completing an 89-yard drive.

Looking to clinch a playoff berth and avenge their Week 3 loss against the Falcons, the Saints traveled to Atlanta for a Monday Night rematch.

In the first quarter the Saints trailed early as kicker Connor Barth hit a 43-yard field goal, but took the lead with QB Drew Brees throwing a 4-yard TD pass to TE Jimmy Graham.

The Buccaneers replied with QB Josh Freeman completing a 2-yard TD pass to WR Dezmon Briscoe, but the Saints tied the game with kicker Garrett Hartley nailing a 45-yard field goal.

New Orleans delivered the game's opening strike in the first quarter with a 26-yard field goal from kicker Garrett Hartley, followed by quarterback Drew Brees finding fullback Heath Evans on a 1-yard touchdown pass.

The Seahawks continued to hack away in the third quarter as Hasselbeck threw a 38-yard touchdown pass to wide receiver Mike Williams, followed by Mare's 39-yard field goal.