In the third quarter, the 49ers struggled further when quarterback Alex Smith threw an interception to cornerback Marcus Trufant, which was returned 32 yards for a touchdown.
Hoping to rebound from their divisional road loss to the Seahawks, the 49ers played their Week 2 home opener against the defending Super Bowl champion New Orleans Saints on Monday night.
San Francisco trailed early in the first quarter as center David Baas' high snap deep within Niner territory resulted in a safety.
The Saints would add onto their lead as quarterback Drew Brees completed a 6-yard touchdown pass to running back Reggie Bush.
The 49ers would respond in the second quarter with quarterback Alex Smith finding running back Frank Gore on a 12-yard touchdown pass.
San Francisco would tie the game with Gore's 7-yard touchdown run, followed by Smith's 2-point conversion pass to tight end Vernon Davis.
[7] In the 2nd quarter, the 49ers trailed early as QB Matt Cassel completed a 31-yard TD pass to WR Dexter McCluster.
The 49ers fell further behind when Chiefs' kicker Ryan Succop hit a 32-yard field goal and then in the third quarter when Cassel found WR Dwayne Bowe and TE Tony Moeaki on 45 and 18-yard TD passes, respectively.
In the first quarter the 49ers took the early lead with QB Alex Smith making a 12-yard TD pass to TE Vernon Davis.
The Niners delivered the game's opening strike in the first quarter as quarterback Alex Smith hooked up with wide receiver Michael Crabtree on a 7-yard touchdown pass, but the Eagles would answer with quarterback Kevin Kolb completing an 8-yard touchdown pass to tight end Brent Celek.
The Niners began to rally as Smith found tight end Vernon Davis on a 7-yard touchdown pass, yet Philadelphia answered with a 45-yard field goal from Akers.
San Francisco tried to rally as Smith found running back Frank Gore on a 1-yard touchdown pass, but Philadelphia's defense would hold on for the win.
The Panthers tied the game with QB Matt Moore completing an 18-yard TD pass to WR David Gettis.
They eventually got the lead back in the fourth quarter with Nedney hitting a 38-yard field goal, and with DE Ray McDonald returning an interception 31 yards for a touchdown.
Following an interception by 49ers backup quarterback David Carr, Kasay successfully booted a 37-yard field goal to give the 49ers the loss.
They soon went on a scoring rally to take the lead with QB Troy Smith scrambling a yard for a touchdown, followed by his 28-yard TD pass to WR Michael Crabtree.
The lead was narrowed when QB Kyle Orton made a 1-yard TD pass to WR Brandon Lloyd (with a failed PAT).
The Rams fought back with QB Sam Bradford completing a 5-yard TD pass to WR Danny Amendola.
The 49ers got the lead back with Nedney getting a 47-yard field goal, followed by QB Troy Smith making a 16-yard TD pass to WR Michael Crabtree.
Hoping to rebound from their shutout loss to the Buccaneers, the 49ers flew to the University of Phoenix Stadium for a Week 12 NFC West duel with the Arizona Cardinals on Monday night.
San Francisco made the opening strike in the first quarter as quarterback Troy Smith found wide receiver Michael Crabtree on a 38-yard touchdown pass.
San Francisco added onto their lead in the second quarter with an 8-yard touchdown pass from running back Brian Westbrook.
Hoping to rebound from their loss to the Packers the 49ers played on home ground for an NFC West rivalry match against the Seahawks.
The 49ers made a large scoring rally to increase their lead when kicker Jeff Reed hit a 33 and a 44-yard field goal, followed by Smith completing a 15 and a 62-yard TD pass to Josh Morgan and Brian Westbrook respectively.
This was followed by Reed making a 22-yard field goal, and in the third quarter with FS Dashon Goldson returning an interception 39 yards for a touchdown.
The lead was broken down with RB Leon Washington returning the kickoff 92 yards for a touchdown, followed in the 4th quarter by QB Matt Hasselbeck getting a 2-yard TD pass to WR Deon Butler.
The 49ers struggled in the first quarter when Steven Jackson got a 1-yard TD run, followed by QB Troy Smith getting sacked in the endzone by DE James Hall for a safety.
They got back in the game after Ted Ginn Jr. returned a punt 78 yards for a touchdown, but fell further behind after kicker Josh Brown nailed a 43-yard field goal.
The 49ers took the lead as QB Alex Smith completed a 37-yard TD pass to WR Ted Ginn Jr., followed in the 2nd quarter by kicker Jeff Reed making a 39-yard field goal.
The Cardinals narrowed the lead as QB John Skelton completed a 10-yard TD pass to WR Larry Fitzgerald, but the 49ers extended their lead after Smith completed a 59-yard TD pass to TE Vernon Davis, followed by RB Brian Westbrook running 6 yards to the endzone for a touchdown twice in succession.