McNabb was traded to Philadelphia's NFC East rival, the Washington Redskins, while Westbrook was cut from the roster and later signed with the San Francisco 49ers.
[45] In the second round of roster cuts, the Eagles waived cornerback Geoff Pope, defensive end Pannel Egboh, defensive tackle Boo Robinson, cornerback David Pender, wide receiver Dobson Collins, tight end Nate Lawrie, offensive tackle Jeraill McCuller, running back J. J. Arrington, safety Anthony Scirrotto and running back Martell Mallett on September 3.
The Eagles donned their throwback uniforms (in celebration of the franchise's 50th Anniversary of their 1960 championship team) and began their season at home for an NFC duel with the Green Bay Packers.
Just four plays into the following drive, the Eagles took the early lead when QB Michael Vick bombed a 45-yard TD pass to deep threat WR DeSean Jackson.
After a Lions punt, the Eagles marched 89 yards in less than a minute with QB Michael Vick throwing a 9-yard TD pass to WR Jeremy Maclin.
After forcing a three-and-out, the Lions stormed 56 yards in just 6 plays, culminating with Hill completing a 19-yard TD pass to WR Calvin Johnson (With a successful 2-point conversion).
Coming off their dominating road win over the Jaguars, the Eagles went home for their Week 4 NFC East duel with the Washington Redskins, as quarterback Donovan McNabb made his highly anticipated return to Philadelphia.
Hoping to rebound from their divisional home loss to the Redskins, the Eagles flew to Candlestick Park for a Week 5 Sunday night duel with the San Francisco 49ers.
The 49ers began to rally as Smith connected a 7-yard touchdown pass to tight end Vernon Davis, yet Akers came right back as he gave Philadelphia a 45-yard field goal.
San Francisco tried to rally as Smith completed a 1-yard touchdown pass to running back Frank Gore, yet Philadelphia's defense held on to preserve the victory.
The Eagles replied with QB Kevin Kolb making a 5-yard TD pass to WR Riley Cooper, followed by kicker David Akers hitting a 46-yard field goal.
The Colts narrowed the lead when James got a 1-yard TD run, but in the final minute Manning lofted a deep pass that was intercepted by Asante Samuel.
Coming off their home win over the Colts, the Eagles flew to FedExField for a Week 10 NFC East rematch with the Washington Redskins on Monday night.
Philadelphia wasted no time kicking off the first quarter as on the very first play of the game, quarterback Michael Vick found wide receiver DeSean Jackson on an 88-yard touchdown pass.
Coming off their impressive win over the Redskins, the Eagles went home for a Week 11 NFC East duel with the New York Giants on Sunday night.
Philadelphia added onto their lead in the third quarter with Akers' 28-yard field goal, yet New York replied with quarterback Eli Manning completed a 2-yard touchdown pass to tight end Travis Beckum.
The Eagles tried to cut the lead with QB Michael Vick getting an 8-yard TD pass to WR Jeremy Maclin, followed by Akers hitting a 36-yard field goal.
The Eagles tried to narrow the lead as Akers got a 22 and a 36-yard field goal, followed by Vick throwing a 30-yard TD pass to TE Brent Celek, but the Bears' defense prevented any more scoring chances.
Hoping to rebound from their road loss to the Bears, the Eagles went home for a Week 13 interconference duel with the Houston Texans on Thursday night.
Philadelphia delivered the opening strike in the first quarter as quarterback Michael Vick found running back LeSean McCoy on a 1-yard touchdown pass.
In the first quarter the Eagles trailed early as Giants quarterback Eli Manning completed a 35-yard touchdown pass to wide receiver Mario Manningham.
After the game was tied the Eagles scored to take the lead with DeSean Jackson returning a punt 65 yards for a touchdown as time expired, becoming the first player in NFL history to do so.
Philadelphia delivered the game's opening punch in the first quarter as quarterback Michael Vick found rookie tight end Clay Harbor on a 3-yard touchdown pass.
Eagles COO Don Smolenski said the possibility of having over 72,000 people (over 69,000 fans plus 3,000 workers) stranded in the brunt of the storm made league and team officials conclude "it just wasn't safe" to play the game on Sunday night.
[96] Indeed, SEPTA and New Jersey Transit, which are utilized by many Eagles fans coming to and leaving games, were forced to alter or cancel routes due to the storm.
Pennsylvania Governor Ed Rendell, the former mayor of Philadelphia and an avid Eagles fan, said that football was a game that was meant to be played in bad weather.
However, Nutter maintained that the city could have had Lincoln Financial Field ready in time for kickoff, and the postponement decision was made by the league and the Eagles.
With their playoff position locked and basically all starters resting, the Eagles' sixteenth game was an NFC East rivalry rematch against the Cowboys.
The Eagles drove into scoring range early in the 4th quarter, but Akers missed another field goal, this time a chip shot from 34 yards, keeping it at 21–10.
However, Green Bay's defense stopped the Eagles' final drive of the game as Tramon Williams intercepted a Vick pass intended for Riley Cooper again, in the end zone, with 44 seconds to go to preserve the win for the Packers.