The 2010 MNL Grand Royal is the Myanmar National League's first full regular season.
The MNL was founded in 2009, and two separate cup competitions were held.
Mandalay-based Yadanabon FC won both competitions.
The title deciding match was also between the champion Yadanabon and Zeya Shwe Myay on 9 November 2010 and Yadanabon won the match 2–1.
The last match of the 2010 season was played on 10 November 2010 between Yangon United F.C.