The 2010 Mercury Insurance Open was a women's tennis tournament played on outdoor hard courts.

It was the first edition of the Southern California Open since the tournament left the tour in 2007.

It was played in San Diego, California, United States.

Unseeded Svetlana Kuznetsova won the singles title.

Svetlana Kuznetsova defeated Agnieszka Radwańska, 6–4, 6–7(7–9), 6–3 Maria Kirilenko / Zheng Jie defeated Lisa Raymond / Rennae Stubbs, 6–4, 6–4 The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following player received entry by a lucky loser spot: