These holes were filled primarily through the draft and a trade that sent Wells Thompson and Jeff Larentowicz to the Colorado Rapids in exchange for defender Cory Gibbs and Goalkeeper Preston Burpo.

[2] The Revs began training for the 2010 Major League Soccer season on February 1, 2010 inside the Dana Farber Fieldhouse at Gillette Stadium, the same indoor practice facility used by the New England Patriots.

The team did most of its preparations for the season in Foxborough, but took two preseason road trips, one to Orlando in February, and the other to North Carolina in March.

[6] The Revs finished their preseason schedule with a 2–1 win over the Carolina Railhawks in which Schilawski scored the game winner in the 87th minute.

After going down 1–0 in the fourteenth minute, the Revs equalized through an impressive free kick by Marko Perović, the Serbian's first MLS goal.

[10] On April 26, the Revs announced that midfielder Shalrie Joseph had been granted an indefinite leave of absence from the team for personal reasons.

The team again struggled to maintain possession, and were lucky to come away with a point after both Kheli Dube and Joseph Niouky were ejected in the second half.

[19] Castro's departure leaves the team with a vacant roster spot, which could be filled by one of the three trialists joining the Revs for their friendly against Benfica.

Serbian defender Ivan Gvozdenovic (a former teammate of current Rev Marko Perovic), English defensive midfielder and 2010 SuperDraft pick Jason Griffiths, and Haiti national team player Jean-Baptiste Fritzson were all available and played against Benfica.

[20] On May 21, Frank Dell'Apa reported on the Boston Globe's Corner Kicks blog that Shalrie Joseph would be available for the following day's game against Toronto FC after completing a 5-game suspension as part of his entrance into the league's substance abuse program.

The Revs were back in action on June 13 for a friendly against Brazilian club Cruzeiro, which they lost 3–0 on a hat-trick by Wellington Paulista.

[22] When the Revs' regular season returned to action on June 27, the team's poor form continued with a 1–0 home defeat to the Chicago Fire.

The MLS all-time leader in assists, appearances, starts, and minutes was given back the number 14, which he had worn in his first stint with the club.

[26] The Revolution looked unlikely to fare much better against the league leading LA Galaxy at Gillette Stadium the following week, but surprised many by pulling out a 2–0 win, the team's first victory since May.

The team was drawn into group B, which also included the Chicago Fire from MLS and Mexican sides Pumas UNAM and Monarcas Morelia.

[30] Former Revolution captain Steve Ralston announced his retirement from professional soccer after the team's SuperLiga match against Morelia on July 20.

Ralston had played in only one game during his return to the Revs, a friendly defeat to Brazilian club Cruzeiro during which he dislocated his elbow.

[32] These spots were then filled on July 30, when the team announced the signings of Serbian forward Ilija Stolica and Brazilian midfielder/forward Roberto Linck.

The Revs will host the SuperLiga final on September 1 at 7 p.m.[34] The club's first league match of the month was a 1–0 win over D.C. United in Foxborough on August 7.

After taking an early lead and conceding a late equalizer, the Revs looked likely to get at least some points out of the match until a Philly found a stoppage time winner from Justin Mapp.

[40] Despite regularly featuring in Steve Nicol's lineup throughout the season, Niouky was never popular with Revs fans, who felt he failed to contribute on the pitch.

Instead of succumbing, however, the Revolution battled back, eventually winning the match 3–1 on goals from Chris Tierney, Marko Perovic, and Kheli Dube, who returned after a lengthy injury absence.

[44] Their road trip continued midweek at FC Dallas, where the Revs took the Hoops by surprise, jumping out to a 2–0 lead on goals from Shalrie Joseph (his first of the year) and Ilija Stolica.

[45] Things started well for the Revs against Columbus four days later, but ended in a case of deja vu for the home team.

New England possessed the ball well against the defending MLS Cup champs, and looked destined to capture a share of the points after Kenny Mansally's 82nd-minute equalizer, but just two minutes later Álvaro Saborío gave Salt Lake the win.

[48] The club's good run of form finally turned into three points the following week, when the Revs defeated the Houston Dynamo 2–1 for just their second road win of the season.

[50] Before their final home match of the year against Kansas City on October 16, the Revolution announced the winners of their 2010 team awards.

[52] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.