The 2010 Vancouver Whitecaps FC season was the club's 35th year of existence, as well as their 24th and final year as a second-tier club.

Following the end of the season, the Whitecaps FC joined MLS, becoming the second Canadian club to enter the league.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

(As of End of 2009 season to Present)