[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

For the second straight year, the Earthquakes played at PDL team Fresno Fuego.

The Quakes trained in London for ten days and went 3–0 against fellow MLS side Colorado Rapids and the reserve teams of West Ham United and Tottenham Hotspur.

San Jose will begin its thirteenth Major League Soccer regular season at home with a match against Real Salt Lake on March 27, 2010, followed by a road match against the Chicago Fire on April 10, 2010.

[18] The Quakes tallied four straight shutouts and a 393-minute scoreless streak, which ended with a 3–1 home loss to Toronto F.C.