The winners of the semifinals will advance to the finals, which will determine the tournament champion.
USAC and Xinabajul finished in 11th and 12th place, respectively, in the overall table of last season and were relegated to the Primera División.
Taking their places were the two winners of the Primera División promotion playoffs, Petapa and Zacapa.
The 2011 Torneo Apertura began on 9 July 2011 and ended on 18 December 2011.
The 2012 Torneo Clausura will begin on 14 January 2012 and will end in May 2012.