During the season, Manning set numerous individual, franchise and league records, including 300-yard passing games and game-winning drives in the fourth quarter or overtime.

With 9:23 remaining in the fourth quarter, the Broncos claimed the lead for good, when Manning threw a 1-yard touchdown pass to tight end Jacob Tamme (coupled with running back Willis McGahee receiving a pass from Manning for a two-point conversion), then added to their lead with a 26-yard field goal by placekicker Matt Prater, followed by cornerback Tracy Porter returning an interception off Roethlisberger 43 yards for a touchdown (with a failed two-point conversion attempt).

The Texans increased their lead in the third quarter, with a 41-yard field goal by placekicker Shayne Graham, followed by a 14-yard touchdown pass from Schaub to tight end Owen Daniels.

Hoping to snap a two-game losing streak, the Broncos remained on home ground for an AFC West duel against the Oakland Raiders.

The Broncos grabbed the early lead, with quarterback Peyton Manning throwing a 22-yard touchdown pass to tight end Joel Dreessen.

Hoping to rebound from their loss at New England, the Broncos traveled to Qualcomm Stadium for an AFC West duel with the San Diego Chargers on Monday Night Football.

The Chargers jumped out to a 10–0 lead in the first quarter, with a 32-yard field goal by placekicker Nick Novak, followed by a 15-yard touchdown pass from quarterback Philip Rivers to tight end Antonio Gates.

On the Chargers' next possession, Broncos' defensive end Elvis Dumervil forced a fumble off Rivers, and cornerback Tony Carter scooped up the football and returned it 65 yards for a touchdown.

On the Chargers' next possession, Carter picked off Rivers, and four plays later, Manning tossed a 21-yard touchdown pass to wide receiver Brandon Stokley to give the Broncos a 28–24 lead with 9:09 remaining in the fourth quarter.

The Chargers once again tried to rally, but six plays later, Harris stepped in front of another Rivers' pass, returning an interception 46 yards for a touchdown, sealing the win for the Broncos.

Coming off their miraculous comeback in San Diego and subsequent bye week, the Broncos returned home for an interconference duel against the New Orleans Saints.

On the Broncos' next possession, McGahee committed a fumble, and the Saints responded early in the second quarter, with quarterback Drew Brees throwing his 300th career touchdown pass—a 29-yarder to running back Darren Sproles.

Quarterback Peyton Manning tossed a 13-yard touchdown pass to wide receiver Eric Decker and placekicker Matt Prater nailed a 33-yard field goal to close out the first half.

The Saints scored a late touchdown, with Brees connecting on an 18-yard pass to wide receiver Jimmy Graham, but the game had already been decided in the Broncos' favor.

[103] Notes Linebacker Joe Mays suffered a fractured fibula on a kickoff return during the fourth quarter, and was placed on the season-ending injured reserve the following day (October 29).

Green, a 49-field goal by Nugent followed in the fourth quarter by running back BenJarvus Green-Ellis rushing for a 2-yard touchdown, with the latter two scores coming off Manning interceptions.

Hoping to add to a four-game winning streak, the Broncos returned home for an AFC West rematch with the San Diego Chargers.

The Chargers grabbed the lead in the first quarter, with safety Eric Weddle returning an interception off Broncos' quarterback Peyton Manning 23 yards for a touchdown.

After linebacker Wesley Woodyard recovered a Rivers' fumble deep in Chargers' territory, the Broncos increased their lead, with Manning throwing a 20-yard touchdown pass to wide receiver Eric Decker.

Hoping to add to a five-game winning streak, the Broncos traveled to Arrowhead Stadium for an AFC West duel with the Kansas City Chiefs.

The Broncos grabbed the lead just before halftime, with quarterback Peyton Manning throwing a 7-yard touchdown pass to tight end Jacob Tamme.

The Chiefs re-claimed the lead in the third quarter, with a 49-yard field goal by Succop, however, the Broncos responded, with Manning connecting on a 30-yard touchdown pass to wide receiver Demaryius Thomas.

The Broncos grabbed the early lead, when defensive tackle Mitch Unrein, lining up as a fullback, caught a 1-yard touchdown pass from quarterback Peyton Manning.

This was the 12th division title in the Broncos' franchise history, tying the Oakland Raiders for the all-time lead in AFC West championships since the 1970 AFL–NFL merger.

A 56-yard touchdown pass from Palmer to wide receiver Darrius Heyward-Bey (with a failed two-point conversion attempt) was the only scoring play of the fourth quarter, and the Broncos ran out the final 5:36 of the game.

Hoping to add to a ten-game winning streak and gain momentum into the playoffs, the Broncos remained at home for an AFC West divisional rematch with the Kansas City Chiefs, in the 2012 regular season finale.

[120] By virtue of the Houston Texans' 28–16 loss to the Indianapolis Colts earlier in the day, the Broncos clinched a first-round bye and homefield advantage throughout the AFC playoffs.

After each team's offense subsequently went three-and-out, the Broncos marched down the field on a 10-play, 88-yard drive, culminating with Manning throwing a 17-yard touchdown pass to wide receiver Demaryius Thomas midway through the fourth quarter.

Three plays later, and with no timeouts, Flacco launched a 70-yard touchdown pass to wide receiver Jacoby Jones to tie the game at 35 with 31 seconds remaining to force overtime.

[126] Numerous individual, franchise and league records and milestones were either tied, reached or broken during the season: Seven Broncos were elected to the 2013 Pro Bowl.