The Panthers gained the lead when quarterback Cam Newton made a 3-yard touchdown pass to wide receiver Steve Smith with 3:13 left in the first half.

The Seahawks continued to dominate the second half when quarterback Russell Wilson threw a 43-yard touchdown pass to wide receiver Jermaine Kearse in the fourth quarter with 10:13 remaining in the game.

The Panthers were on the verge of scoring, however running back DeAngelo Williams fumbled the ball at the Seattle 8-yard line with 5:25 left in the game and the Seahawks recovered.

With 20 seconds remaining in the game from the Panthers' 31, Manuel threw an interception, but it was called back due to Luke Kuechly, the linebacker, committing pass interference.

With 2 seconds remaining from the Panthers' 2-yard line, Manuel hit wide receiver Stevie Johnson in the back of the end zone for the score.

The Panthers romped the Giants (0–3) 38–0 behind seven defensive sacks and the flashy play of offensive weapons like Cam Newton and DeAngelo Williams.

For the first time in franchise history the Panthers scored 30 or more points in four consecutive games, routing NFC South rival Atlanta Falcons 34–10.

The reigning NFC champions San Francisco, coming off a bye, only managed three field goals, partly due to the absence of start wide receiver Michael Crabtree and an early injury to tight end Vernon Davis.

The Panthers finally responded on their next drive, storming 80 yards in just 8 plays with DeAngelo Williams bursting through for a 27-yard touchdown run, trimming the score to 9–7 at halftime.

On the Panthers second drive of half they drove, 59 yards taking 5:44 off the clock, but Graham Gano missed a 48-yard field goal.

The 49ers responded by driving to the Panthers 39, but Kendall Hunter was stripped by linebacker Thomas Davis and Quintin Mikell recovered for Carolina.

After both teams punted on their next two drives, Drayton Florence made up for his earlier mistake with an interception with 0:37 left to seal the 10–9 Carolina statement victory.

Down 17–20 with less than a minute left, Panthers quarterback Cam Newton threw a 25-yard touchdown to wide receiver Ted Ginn Jr., bringing Carolina up 24–20.

However, a flag was thrown by back judge Terrence Miles just after the ball was intercepted because Patriots tight end Rob Gronkowski, the intended target, was wrapped up by Panthers linebacker Luke Kuechly.

However, after the officials talked it over, they picked up the flag and ruled that the pass was uncatchable due to it being underthrown, and the game ended in a Panthers win.

The prime time victory, before one of the largest crowds in franchise and Bank of America Stadium history, extended the Panthers' winning streak to six, increased their record to 7–3 and improved to 14–4 when Newton does not turn the ball over.

With the loss, the Panthers fell to 2nd place in the NFC South sitting at 9–4 as they also dropped to 14–5 when Newton doesn't turn the ball over.

The Panthers came into the game hoping to avenge their loss to the Saints two weeks prior, with the winner taking first place in the NFC South.

With under a minute to play, Newton threw the game-winning touchdown pass to receiver Domenik Hixon, who was replacing an injured Steve Smith Sr.

Hawley later said that he was distracted by the noise from a large number of Panther fans who made the five-hour drive to Atlanta, and thought Ryan was calling for the ball.

With the win, the Panthers clinched the NFC South, the #2 seed and a first-round bye, finishing 12–4 in the progress while going 10–18 when Newton turned the ball over.