While losing their Week 14 match-up against the Cincinnati Bengals, the Colts clinched their 15th division title after the Denver Broncos defeated the Tennessee Titans and their first without Peyton Manning.

This game marked the return of starting quarterback Andrew Luck to the San Francisco Bay Area, where he played three seasons of college football at Stanford University, which for his first two years there was coached by Jim Harbaugh, then-coach of the 49ers.

The Raiders, who received the opening kickoff, would turn the ball over on a Terrelle Pryor interception by Colts cornerback Greg Toler.

Heading into the second quarter, the Colts defense would continue to prevent the Raiders from scoring, forcing Oakland to punt on second drive of the game.

[34] Pryor and the Raiders would respond for the first time on their next offensive drive, which ended in a touchdown run from Darren McFadden.

This game also marked the second meeting between Andrew Luck of the Colts and Ryan Tannehill of the Dolphins, both sophomore quarterbacks.

[38] The Dolphins would strike again, this time scoring in just two plays following a Tannehill 67-yard pass and a Lamar Miller touchdown run.

The Colts, who entered the second quarter trailing 14–3, quickly scored their first touchdown on the day with an Andrew Luck pass to tight end Coby Fleener.

After trading possessions, the Indianapolis offense would strike again, scoring their second touchdown of the quarter and taking the first lead of the day, though it would be taken away by a Caleb Sturgis field goal to end the half, with the teams going into halftime tied at 17.

Indianapolis would drive down on their first possession of the second half, though a touchdown would be nullified by an illegal shift penalty and forcing the Colts to settle for a field goal.

With the loss, the Colts dropped to 8–5, however, they clinched the AFC South division title after the Broncos defeated the Titans later in the evening.