The first play of their season was a mental error by kick returner Darius Reynaud, who tried to kneel down for a touchback, but fielded the ball just outside the end zone, which resulted in a safety for Pittsburgh.
Notwithstanding, Tennessee got off to a strong start, scoring a touchdown and 3 field goals for a 16-2 lead.
With the convincing win, the Titans started the season at 1-0, but since the Colts beat the Raiders, 21-17, and the Texans later defeated the Chargers, 31-28, Tennessee tied for 1st place in the AFC South, since the Jacksonville Jaguars were humiliated, 28-2, at home by the Kansas City Chiefs.
For the first time since 1992 the Titans franchise defeated the Chargers, winning on a 34-yard touchdown throw from Jake Locker to Justin Hunter with 15 seconds to go.
Geno Smith of the Jets was intercepted twice, but the most-popularized play came when he fumbled behind his back at the Titans goalline and Karl Klug fell on the touchdown.
For the first time in 7 years, it was also quarterback Ryan Fitzpatrick's first return to St. Louis since he was traded from the Rams following the 2006 season.
The game lead tied or changed on every score as the Titans erupted to 198 rushing yards and four touchdowns on the ground.
With the loss, coupled with the Miami Dolphins' win, the Titans were officially eliminated from playoff contention.