Week 7 saw Sam Bradford make his final appearance in a Rams uniform, as he tore his ACL in a game against the Carolina Panthers.

Not only did the Rams lose the game 15–30, but they lost two starters; defensive end Chris Long was ejected after throwing a punch and quarterback Sam Bradford suffered a season-ending knee injury after running out of bounds.

With Kellen Clemens taking over for the rest of season, the Rams defense played lights out, sacking Russell Wilson seven times and allowing just 135 total yards.

The Rams harassed Andrew Luck and the Colts all game long, stunning Indy with a 38-8 blowout.

With the loss, the Rams clinched their 10th consecutive non-winning season, and were officially eliminated from playoff contention.

The Rams defense shut down the Buccaneers' offense throughout the game, but Jake Long tore his ACL, ending his season.