The 2015–16 Mississippi State Bulldogs women's basketball team represented Mississippi State University during the 2015–16 NCAA Division I women's basketball season.

The Bulldogs were led by fourth year head coach Vic Schaefer.

They played their home games at Humphrey Coliseum and were members of the Southeastern Conference.

They advanced to the championship game of the SEC women's tournament, where they lost to South Carolina.

They received an at-large bid to the NCAA women's tournament, where they defeated Chattanooga and Michigan State in the first and second rounds before getting dismantled by Connecticut by 60 points in the sweet sixteen, the largest defeat in Bulldogs women's basketball history.