[9] On 13 June, Chelsea announced it had released Marco Amelia and Kevin Wright,[10] and also confirmed that loanees Radamel Falcao and Alexandre Pato would be returning to their respective teams.

[12] On 27 June Chelsea youngster Kyle Scott joined Dutch club Willem II on trial after handing in multiple transfer requests in April 2016.

After being linked with multiple teams, on 6 July Jérémie Boga joined La Liga side Granada on a season-long loan.

[31] In the following match of its Austrian tour, Chelsea won 3–0 against Wolfsberger AC, with youngsters Bertrand Traoré, Ruben Loftus-Cheek and Nathaniel Chalobah each scoring a goal.

[33] On 28 July, Chelsea started its tour of the United States with a 1–0 victory over Premier League rival Liverpool thanks to an early goal from Gary Cahill.

[39] On 5 August, Abraham signed for Championship side Bristol City on a season-long loan, with no recall clause[40] and Papy Djilobodji joined Sunderland for a fee reported to be in the region of £8 million.

[49] On 23 August, Marko Marin joined Greek side Olympiacos on a three-year deal for a fee thought to be in the region of £3 million.

[55] Chelsea started its Premier League season with a 2–1 win over London rivals West Ham United, with goals scored by Eden Hazard and Diego Costa.

[64] Cristián Cuevas returned to Sint-Truiden[60] for a second season while Islam Feruz joined fellow loanee Matej Delač at Mouscron-Péruwelz.

[68] His return was completed after he insisted on the move and stated that it was a "good deal" for the French champions after the club had initially refused the offer.

After suffering back-to-back Premier League losses to top-four rivals Liverpool and Arsenal, Antonio Conte switched to a 3–4–3 formation against Hull City on the 1 October which earned him a 2–0 victory, thanks to a goal apiece from Willian and Diego Costa.

The game was marred by crowd disturbances amongst both sets of rival fans, with plastic bottles, coins and seats being thrown across the London Stadium.

Spurs' miserable record at Stamford Bridge was extended to 30 games without a win – dating back to February 1990 – after Victor Moses scored what proved to be the winner six minutes after the restart.

The match ended in a wide-scale brawl that occurred as a result of a Sergio Agüero two legged lunge tackle on Chelsea defender David Luiz.

[96] César Azpilicueta made his 200th appearance for the Blues in the match, just one day after signing a three-and-a-half-year contract that will keep him at the club through the 2020 season.

Diego Costa and N'Golo Kanté both accumulated their fifth yellow cards of the season, resulting in themselves not being available for selection in the Boxing Day match against AFC Bournemouth.

[104] On 31 December, Chelsea equalled a top flight record of 13 consecutive wins in a single season with a thrilling 4–2 home victory over Stoke City.

Goals from Gary Cahill with a headed effort, a second-half brace from Willian to help Chelsea regain the lead on two occasions in the match, and an 85th minute Diego Costa strike sent the Blues nine points clear of second-placed Liverpool going into the New Year, with Liverpool being able to cut the deficit to six points should they earn a victory against fellow title challengers Manchester City.

[106] On 1 January, goalkeeper Jamal Blackman extended his loan spell with League Two club Wycombe Wanderers until the end of the 2016–17 season.

A brace from midfielder Dele Alli with goals just before and after half time, prevented Chelsea from writing Premier League history with a fourteenth successive win.

However, the result itself did not affect Chelsea's position in the Premier League, with the Blues remaining in first place and five points clear of second-placed Liverpool following their draw with Sunderland.

Mason was sent to hospital and it was later confirmed that he sustained a skull fracture, while Cahill remained on the pitch and secured the victory with a header goal in the second half.

[118] Youngsters Fikayo Tomori and Mukhtar Ali joined Brighton & Hove Albion and Vitesse respectively on loans until the end of the season.

On 1 April, having taken the lead through Cesc Fàbregas, Chelsea lost 2–1 at home to South London club Crystal Palace, with all the goals being scored in the first eleven minutes.

On 16 April, Manchester United exacted revenge for being eliminated from the FA Cup the previous month with league victory over Chelsea at Old Trafford.

On 25 April, Chelsea were 4–2 winners over Southampton: Eden Hazard and Gary Cahill netting in the first half and a Diego Costa double in the second-half; former Blues Oriol Romeu and Ryan Bertrand scored for Saints.

On 8 May, goals from Diego Costa, Marcos Alonso and Nemanja Matić were enough to relegate visitors Middlesbrough back to the English Football League after just one season in the top-flight.

On 12 May, Chelsea defeated West Bromwich Albion 1–0 to clinch the Premier League title as they went ten points clear with two games remaining.

The Hertfordshire club gave the champions-elect that day a guard of honour; this included Kenedy, the player making his Chelsea league début having made one appearance for Watford earlier in the season before his loan deal was cancelled.

[126] On 21 May, Chelsea defeated already-relegated Sunderland 5–1 with goals from Willian, Eden Hazard, Pedro and a brace from Michy Batshuayi – his fourth in three matches.