The 2016 season was the Kansas City Chiefs' 47th in the National Football League (NFL), their 57th overall and their fourth under head coach Andy Reid and the fourth and final season under general manager John Dorsey who was fired June 22, 2017.

[1] The Chiefs clinched their first AFC West division title since 2010, beginning a streak of nine consecutive that still stands as of 2024.

The Chiefs also clinched a first-round bye for the first time since 2003, but lost to the Pittsburgh Steelers in the Divisional round 18–16.

On March 9, 2016, the NFL announced that the Chiefs had violated the league's anti-tampering policy while pursuing wide receiver Jeremy Maclin during the 2015 off-season.

The NFL defines tampering as prospective teams contacting soon-to-be free agents before NFL policies allow, which is two days prior to the beginning of the new league year.

*Trade included a conditional draft pick that required Davis to stay on the roster for a specific amount of time; since he did not meet this requirement, the Chiefs received no compensation.

*Indicates player was signed off practice squad of team listed†Knile Davis was traded to the Packers, then was released 2 weeks later, and signed back to the Chiefs This list is for players who were involved in more than one transaction during the season Front office Head coaches Offensive coaches Special teams coaches Strength and conditioning