Carson Palmer, the starting quarterback for the previous five seasons, retired in the offseason.

To replace him, the Cardinals signed veteran quarterbacks Sam Bradford and Mike Glennon, also selecting Josh Rosen in the first round of the draft.

While Rosen took over the starting job by week 4, he and Bradford struggled throughout the season with Glennon only playing sparingly.

The Cardinals also tallied a 1–7 record at home, the worst in franchise history until it was tied by four years later.

Head coach Steve Wilks was fired the day after the season ended.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

Rosen's first start was a loss as the Seahawks kicked a game-winning field goal.

This was the first time the Cardinals defeated the Packers on the road since 1949 when the team was based in Chicago.