Quarterback Marcus Mariota had a difficult season, going 7–6 as a starter, throwing 11 touchdowns to eight interceptions, and missing three games due to injury.

Backup quarterback Blaine Gabbert started three games, including the season finale against the Colts in which the Titans were eliminated from the playoffs.

The Titans won their first playoff game since 2003 in an 18-point halftime comeback wild card victory over the Kansas City Chiefs, winning 22–21.

[2] The next day on January 15, 2018, the Titans and Mularkey agreed to part ways, ending his three-year tenure as head coach with a record of 20–21.

[7] Pees had retired two weeks earlier with the Baltimore Ravens, citing his comeback with the Titans due to missing the game.

[10] On March 15 the Titans signed two notable former New England Patriots players, running back Dion Lewis and cornerback Malcolm Butler.

[11][12] The two reunited with current cornerback Logan Ryan, who also played for the Patriots, in which their last season in New England together was capped off with a Super Bowl comeback win.

The Titans signed their new back-up quarterback on March 26, seven-year veteran Blaine Gabbert, after releasing Matt Cassel earlier in the offseason.

[15] On August 28, shortly before their final preseason game, the Titans traded their sixth round pick in the 2019 NFL draft to the Baltimore Ravens for outside linebacker Kamalei Correa.

[16] Source:[19] Front office Head coaches Offensive coaches Special teams coaches Strength and conditioning Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Source:[20] On January 11, 2018, the NFL announced that the Titans would play the Los Angeles Chargers in one of three London Games at Wembley Stadium in London, England, with the Chargers serving as the home team.