The Lions took an early lead in the first quarter when Quandre Diggs intercepted a Sam Darnold pass and ran it in from 37-yards, but the Jets quickly tied it up following a seven-yard touchdown run from Isaiah Crowell.

In the second quarter, the Jets scored 10 more points via a 35-yard field goal by Jason Myers and a 41-yard touchdown pass from Darnold to Robby Anderson.

After the intermission, the Lions again tied the game following a 24-yard touchdown pass from Matthew Stafford to Golden Tate, for their only points of the second half.

After a 32-yard field goal by Jason Myers, the Jets capped off their lopsided win with a 62-yard run by Crowell, making the final score 48–17 in favor of New York.

The 49ers scored 10 points in the second quarter via a four-yard touchdown pass from Jimmy Garoppolo to Kendrick Bourne and a 42-yard field goal from Gould.

The Lions scored 10 points in the second quarter via a four-yard touchdown pass from Matthew Stafford to Kenny Golladay and a 25-yard field goal from Prater.

The Patriots finally got on the board late in the quarter via a 36-yard field goal by Stephen Gostkowski, to make the score 13–3 in favor of the Lions at half-time.

The Lions extended their lead in the fourth quarter via two field goals from Prater, from 32-yards and 30-yards, respectively, making the final score 26–10 in favor of Detroit, for their first win of the season.

The Cowboys regained the lead with a 38-yard touchdown pass from Dak Prescott to Ezekiel Elliott, to make the score 13–10 in favor of the Dallas at half-time.

The Lions took a one-point lead when Tate caught a 38-yard touchdown pass from Stafford, but the Cowboys won in the final seconds of the game with a 38-yard field goal by Maher.

In the fourth quarter, Detroit scored their only points of the second half via a five-yard touchdown pass from Stafford to Kenny Golladay.

Green Bay added nine more points via a 12-yard touchdown pass from Rodgers to Davante Adams and a 41-yard field goal from Mason Crosby, making the final score 31–23 in favor of Detroit.

The Lions took an early lead in the first quarter, that they never gave back, following a 15-yard touchdown pass from Matthew Stafford to Michael Roberts.

The Lions added 10 points in the second quarter, via a 29-yard field goal by Matt Prater and a two-yard touchdown run from LeGarrette Blount.

Miami got on the board via a five-yard touchdown pass from Brock Osweiler to Kenny Stills, to make the score 17–7 in favor of the Lions at half-time.

The Dolphins responded with a 24-yard touchdown pass from Osweiler to Danny Amendola, making the final score 32–21 in favor of Detroit.

The Vikings extended their lead via a two-yard touchdown pass from Kirk Cousins to Adam Thielen and a 39-yard field goal by Dan Bailey, to make the score 17–6 in favor of Minnesota at half-time.

First a 32-yard fumble recovery for a touchdown by Danielle Hunter for the Vikings, then a 37-yard field goal by Prater for the Lions, making the final score 24–9 in favor of Minnesota.

The Lions finally got on the board just before the intermission via a one-yard touchdown run by Kerryon Johnson, to make the score 26–7 in favor of Chicago at half-time.

In week 12, the Lions donned retro-style uniforms and hosted a Thanksgiving Day rematch with their division rival the Chicago Bears.

The Bears responded with a 40-yard field goal by Cody Parkey and a 10-yard touchdown pass from Chase Daniel to Taquan Mizzell, to make the score 9–7 in favor of Chicago at half-time.

In the fourth quarter, however, the Bears took a three-point lead via a 14-yard touchdown pass from Daniel to Tarik Cohen, but the Lions quickly tied it up via a 20-yard field goal by Matt Prater.

The Bears regained the lead via a 41-yard interception return by Eddie Jackson, making the final score 23–16 in favor of Chicago.

After a scoreless third quarter, the Bills scored the only points of the second half via a 42-yard touchdown pass from Allen to Robert Foster.

The Lions' attempted comeback failed when Matt Prater missed a 45-yard field goal in the fourth quarter, making the final score 14–13 in favor of the Bills.

In week 16, the Lions played their final home game of the season when they hosted a rematch with their divisional rival the Minnesota Vikings.

The Vikings held the Lions scoreless in the second half and extended their lead in the third quarter via a 24-yard field goal by Dan Bailey, then added 10 more points in the fourth quarter via a four-yard touchdown pass from Cousins to Rudolphand a 29-yard field goal by Bailey, making the final score 27–9 in favor of Minnesota.