On 17 October, Cruzeiro won their 6th Copa do Brasil title after defeating Corinthians 2–1 at Arena Corinthians, becoming the biggest champions of the tournament history and the first to win it twice in a row.

[1] Source: Competitions As Cruzeiro participated in the 2018 Copa Libertadores, the club entered the Copa do Brasil in the round of 16, whose draw was held on 20 April.

The group stage draw for the 2018 Copa Libertadores was made on 20 December 2017.

[3] Cruzeiro were drawn into Group E with Universidad de Chile, Racing and Vasco da Gama.

The draw for the knockout stages of the Copa Libertadores was held on 4 June.