[2] The draw for the second stage was held on 13 May 2019, 20:30 PYT (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.
If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner (Regulations Article 27).
Independiente del Valle won 7–3 on aggregate and advanced to the round of 16 (Match B).
Tied 1–1 on aggregate, Atlético Mineiro won on penalties and advanced to the round of 16 (Match H).
Tied 3–3 on aggregate, Royal Pari won on away goals and advanced to the round of 16 (Match A).