Independiente del Valle won 2–0 on aggregate and advanced to the quarter-finals (Match S2).
Tied 1–1 on aggregate, Colón won on penalties and advanced to the quarter-finals (Match S4).
Tied 2–2 on aggregate, Independiente del Valle won on away goals and advanced to the semi-finals (Match F2).
Tied 1–1 on aggregate, Corinthians won on away goals and advanced to the semi-finals (Match F2).
The final was played on 9 November 2019 at the Estadio General Pablo Rojas in Asunción.