The 2021 Atlantic 10 tournament was originally scheduled to be held from March 10–14, 2021, at Barclays Center in Brooklyn, New York, but due to ongoing impacts from the COVID-19 pandemic, the tournament was moved to campus locations.

The tournament was first scheduled to be played on the same dates but split between the Robins Center at the University of Richmond and the Siegel Center at VCU, but the schedule was later adjusted so that the first four rounds will be played from March 3 to March 6 at those arenas with the championship game to be held March 14 at UD Arena at the University of Dayton.

This table summarizes the head-to-head results between teams in conference play.

[4] Jalen Crutcher, Dayton Tre Mitchell, Massachusetts Kyle Lofton, St. Bonaventure Jordan Goodwin, Saint Louis Bones Hyland, VCU Blake Francis, Richmond Jacob Gilyard, Richmond Jaren Holmes, St. Bonaventure Osun Osunniyi, St. Bonaventure Javonte Perkins, Saint Louis Jordan Miller, George Mason Jamison Battle, George Washington Fatts Russell, Rhode Island Grant Golden, Richmond Vince Williams Jr., VCU Christian Ray, La Salle Tre Mitchell, Massachusetts Jaren Holmes, St. Bonaventure Gibson Jimerson, Saint Louis Jacob Gilyard, Richmond Osun Osunniyi, St. Bonaventure Jordan Goodwin, Saint Louis Hason Ward, VCU Tyler Kolek, George Mason Jhamir Brickus, La Salle Jordan Hall, Saint Joseph's Adrian Baldwin Jr., VCU Two teams from the Atlantic 10 qualified for the NCAA Tournament.

Tournament and regular-season champion St. Bonaventure qualified through the conference's automatic bid, while tournament and regular-season runner-up VCU qualified through an at-large bid.