The 2020–21 Big South Conference men's basketball season began with practices in October 2020, followed by the start of the 2020–21 NCAA Division I men's basketball season in November.

Conference play begins in January 2021 and will conclude in March 2021.

The preseason coaches' poll was announced by the league office on November 10, 2020.

[1] (First place votes in parentheses) Preseason honors were announced by the league office on November 10, 2020.

[2]