The team will participate in the Liga MX and the CONCACAF Champions League.

[2]Note: Flags indicate national team as has been defined under FIFA eligibility rules.

Club América preceded their 2020–21 campaign by taking part in the Copa por México, being placed in Group A alongside Toluca, UNAM, and Cruz Azul.

In November, CONCACAF announced that the remaining fixtures of the Champions League would be held the following month, and would be played at Exploria Stadium in Orlando, Florida.

[17] América, up 3–0 on aggregate, faced Atlanta United in the second-leg of the quarter-finals.