Coming off a disastrous 2019–20 season, which not only ended trophyless for the first time in 12 years, but also produced a humiliating 8–2 defeat to Bayern München in the Champions League, Barcelona looked to bounce back.

Ronald Koeman was brought in as manager in place of Quique Setién, and he immediately emphasized his strive to reform the squad, underscored by the aforementioned departure of Suárez to Atlético Madrid.

In the Champions League, Barcelona finished second in their group and then lost to PSG in the round of 16, breaking their streak of 13 consecutive quarter-final appearances in the competition.

[3] On 21 September, Barcelona reached an agreement with PAOK FC for the transfer of Moussa Wagué on loan for the rest of the season without a buy option.

[4] On 22 September, Barcelona reached an agreement with Inter Milan for the free transfer of Arturo Vidal with €1 million in variables.

[6] On the same day, Barça announced that the club had reached an agreement with Atlético Madrid for the departure of Luis Suárez on a free transfer with €6 million in variables.

A brace from Ansu Fati, a penalty from Lionel Messi, and an own goal from Pau Torres gave Barça the victory.

Luuk de Jong got the visitors off the mark but Philippe Coutinho equalized for the home side shortly after.

Goals from Lionel Messi, Ansu Fati, Philippe Coutinho, Pedri, and Ousmane Dembélé ensured victory for the Blaugrana.

[16] Later that day, Barça announced the contract extensions of Gerard Piqué until 2024, Marc-André ter Stegen until 2025, Frenkie de Jong and Clément Lenglet until 2026.

[21] On 28 October, Barcelona announced that Carles Tusquets would be the interim club president until elections were held.

Luis Rioja would take advantage of a mix-up between Gerard Piqué and Neto to put the home side 1–0 up.

Yannick Carrasco scored the only goal after taking advantage of a mistake from Marc-André ter Stegen.

Álvaro Giménez scored first for the home side but Barça drew level with an own goal from Pedro Alcalá.

[31] On 8 December, Barcelona lost to Juventus 3–0 at home in the Champions League after conceding two penalties converted by Cristiano Ronaldo and a goal from Weston McKennie.

[39] On 6 January, Barcelona and Getafe reached an agreement for the loan of Carles Aleñá for the remainder of the season.

Frenkie de Jong put Barça in the lead after converting a header, but Mikel Oyarzabal equalized for La Real in the second half.

Antoine Griezmann struck first and put Barça in the lead but Óscar de Marcos quickly equalized.

Iñaki Williams scored at the start of extra time and Los Leones won the Super Cup.

[49] On 1 February, Barcelona announced that the club had reached an agreement with Benfica to terminate the loan of Jean-Clair Todibo.

Todibo subsequently joined OGC Nice on loan until the remainder of the season, with an option to buy for €8.5 million.

Barça took the lead in the 100th minute of extra time with a header from Griezmann, but Granada soon equalized with a penalty converted by Fede Vico.

However, Barça again took the lead with a goal from De Jong, and the game was sealed with a rasping volley from Jordi Alba, assuring passage to the semi-finals.

[54] On 16 February, Barcelona lost to Paris Saint-Germain 4–1 at home in the first leg of the Champions League round of 16.

Messi scored from the penalty spot to put Barça in the lead but a hat-trick from Kylian Mbappé and a goal from Moise Kean gave the visitors the victory.

Kylian Mbappé scored from the penalty spot to put Paris in the lead but Messi equalized for Barça shortly after.

First half goals came from Karim Benzema and Toni Kroos, and while Óscar Mingueza pulled one back for the Catalans, however it wasn't enough as the visitors lost the first Clásico at the Alfredo Di Stéfano Stadium.

[66] On 17 April, Barcelona won their 31st Copa del Rey after defeating Athletic Bilbao 4–0 in the final.

A brace from Messi, a header from Araújo, a penalty converted by Griezmann and an own goal secured victory for the home side.

Messi gave Barcelona the lead, but a brace from Santi Mina won the game for Celta.