The 2020–21 Women's EHF Champions League knockout stage began on 6 March and ended on 30 May 2021 with the final at the László Papp Budapest Sports Arena in Budapest, Hungary, to decide the winners of the 2020–21 Women's EHF Champions League.
[1] On 10 February 2021, after a decision by the EHF Executive Committee, it was announced that all 16 teams advanced from the group stage.
The four quarterfinal winners qualified for the final four tournament at the László Papp Budapest Sports Arena in Budapest, Hungary.
Győri Audi ETO KC won 69–48 on aggregate.
Győri Audi ETO KC won 54–40 on aggregate.