The 2020–21 EHF Champions League knockout stage began on 31 March with the playoffs and ended on 13 June 2021 with the final at the Lanxess Arena in Cologne, Germany, to decide the winners of the 2020–21 EHF Champions League.
[1] On 10 February 2021, after a decision by the EHF Executive Committee, it was announced that all 16 teams advance from the group stage.
The four quarterfinal winners qualified for the final four tournament at the Lanxess Arena in Cologne, Germany.
On 29 March 2021 the European Handball Federation has issued an overview on what happens if matches cannot be played in the upcoming play-offs of the EHF Champions League Men due to reasons related to the COVID-19 pandemic.
The final four was held at the Lanxess Arena in Cologne, Germany on 12 and 13 June 2021.