The 2021–22 Drexel Dragons women's basketball team represented Drexel University during the 2021–22 NCAA Division I women's basketball season.

The Dragons, led by second-year head coach Amy Mallon, played their home games at the Daskalakis Athletic Center in Philadelphia, Pennsylvania as members of the Colonial Athletic Association.

They defeated Delaware in the CAA tournament championship, and earned an automatic bid to the 2021 NCAA Division I women's basketball tournament.

Sources: Sources: In a poll of the league coaches, media relations directors, and media members at the CAA's media day, Drexel was picked to finish in first place in the CAA.

[1] Hannah Nihill and Keishana Washington were named to the preseason All-CAA first team.