The 2021–22 season was the 63rd season in the existence of Pau FC and the club's second consecutive season in the second division of French football.

In addition to the domestic league, Pau participated in this season's edition of the Coupe de France.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Source: Soccerway Source: Ligue 2 The league fixtures were announced on 25 June 2021.