The 2021–22 season was the 120th season in the existence of US Quevilly-Rouen Métropole and the club's first season back in the second division of French football since 2018.

In addition to the domestic league, Quevilly-Rouen participated in this season's edition of the Coupe de France.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Win Draw Loss Fixtures Source: Soccerway Source: Ligue 2 The league fixtures were announced on 25 June 2021.