The 2021–22 Second Men's League of Serbia is the 16th season of the Second Basketball League of Serbia, the 2nd-tier men's professional basketball league in Serbia.

A total of 16 teams participated in the 2021–22 Second Men's League of Serbia, divided into two geographical groups with 8 clubs.

[1] In August 2021, the Basketball Federation of Serbia confirmed a disaffiliation of Fair Play and their merge into Spartak.

Spartak took the Fair Play's spot for the 2021–22 season.

[2][3]